Chapter F1. The 'Early Bird' Gets the Breast Cancer Protection (Brent Rooney) Alice and Barbara are identical twins. Alice had her first and only pregnancy at age 18 giving birth to Amy but Barbara waited until she was 33 to have her only pregnancy, a full-term birth (Betsy). Everything else being about equal, who has the higher breast cancer risk, Alice or Barbara? Answer: Barbara has about 68% higher risk of breast cancer than Alice. Is it not just good enough to have a first before age 30? For many decades it has been well known by cancer researchers that women who gave birth had lower breast cancer risk than childless women. Is any particular birth any more important that others? Lead by Harvard's Dr. Brian MacMahon the answer was very dramatic: the first full-term birth was by far the most important in reducing BC risk. (Bulletin WHO, 1970) A woman who has a first full-term birth before age 20 has about 1/2 the BC risk as women who wait until after age 35, according to the "MacMahon" data. In 1983 this data was reanalyzed to give a more precise answer ( International Journal of Cancer, B MacMahon, et al.) Every year a woman waits to have her first full-term pregnancy (FFTP) increases her BC risk by 3.5% ( compounded ); this is relative risk. Compared to a woman with an birth at age 18 the increase in relative BC risks for women at older ages at FFTP (first birth) are as follows: Age at First % increase in birth (FFTP) relative BC risk 20 7% 24 --------- 23% 28 41% 32 --------- 63% 36 86% 39 ---------105% Any confirmation of the "MacMahon" findings? Many subsequent studies verified 'early first birth protection' and it is quite well accepted by medical researchers (called epidemiologists). For example, in 1996 researchers found that each one year delay of first birth increased BC risk by 4.65% compounded ( International J Cancer, pp. 187-189 ). Dr. Susan M. Love is a prominent breast cancer surgeon ( and prominent feminist ). Dr. Love wrote, "And the younger you are when you have your first child, the lower your [breast cancer] risk." (Dr. Susan Love's Breast Book, 1995, page 242) Other advantages from an 'early bird' birth: 1. assurance that a woman will not be childless by menopause time 2. ovarian cancer and endometrial cancer risk reduced by about 1/2 3. reduces total exposure to EXCESS estrogen (since a first birth lowers estrogen levels) 4. women with births will on average live longer than women with NO births. on a net basis, birth is a net life saver for mom. married women without births have 16% higher all-cause mortality than married women with births (British Medical Journal, 1988, pp. 391-395) 5. More opportunity to breast feed and slash BC risk even more 6. less risk of osteoporosis (via having any birth) 7. there is some evidence that women under age 20 who breastfeed have more BC risk reduction (than those who start after age 20). 8. substantially reduced risk of suicide during the pregnancy and in the 12 months after the birth But what do I do, if I missed my early birth opportunity? An early first birth is not the 'be all and end all' for good health for women; you probably know childless older women in very good health. Such women, however, should place special emphasis on an optimum diet, should consistently exercise, & (assuming her doctor approves) do many of the 'health builders' recommended in this document (including NATURAL progesterone creams). Good health is like an orchestra, requiring many 'instruments' to provide a beautiful tune. If you want to maximize your chances of avoiding cancer, there are some 'new' books that can help you; (most of the advice also helps you reduce the most important risk for women: heart attack): Breast Health (Charles B. Simone, MD, Avery Publishing Group) [Simone's book is the most comprehensive BC prevention book] The Breast Cancer Prevention Program (Dr. Samuel S. Epstein, David Steinman, 1997) Also helpful are: How to Prevent Breast Cancer (Vinton C. Vint, MD, et al.) Breast Cancer? Breast Health! (Susan S. Weed) The following two articles are useful: Breast Health Update (Charles B. Simone), Health Counselor mag., June/July 1996, pp. 17-23 No Breast Cancer for My Daughter - How to Reduce the Risk (Brent Rooney), ALIVE magazine, July/August 1995), pp. 17-18 More Recommended Reading: Every Woman's Book (Paavo Airola, ND); informs woman about true prevention Return to the Joy of Health (Zoltan Rona, MD, Jeanne Marie Martin) Dr. Susan Love's Breast Book (Dr. Susan M. Love, 1995) -------------------------------------------------------------------------- The general ideas presented in this article first appeared in the article: An Early First Birth for Breast Cancer Prevention (Brent Rooney, ALIVE, April 1997, #174, pp. 34-35) ALIVE magazine (published monthly) 7436 Fraser Park Drive Burnaby, Canada V5J 5B9 One year subscription for U.S. residents - $40 [1998] [your author has no direct or indirect financial connection to ALIVE magazine] -------------------------------------------------------------------------- Brent Rooney: Previous ALIVE articles: No Breast Cancer for My Daughter How to Reduce the Risk (July/August 1995, pp. 17-18) An Early First Birth for Breast Cancer Prevention (April 1997, pp. 35-36 --------------------------------------------------------------------------- References: ENDOMETRIAL CANCER Brinton LA, et al., Reproductive, menstrual, and medical risk factors for endometrial cancer: Results from a case-control study, American J Obstetrics and Gynecology, 1992; 167:1317-1325 OVARIAN CANCER Joly D, et al., An Epidemiologic Study of the Relationship of Reproductive Experience to Cancer of the Ovary, American J Epidemiology, 1974, 99:190- 209 Whittemore A, et al., Characteristics Relating to Ovarian Cancer Risk: Collaborative Analysis of 12 US Case-Control Studies, American J Epidemiology, 1992, 136:1184-1203 PARITY AND ALL-CAUSE MORTALITY Green A, et al., Mortality in women in relation to their childbearing history, British Medical J, 1988, 297:391-395 REPRODUCTIVE-HORMONAL Daling J, et al., Risk of Breast Cancer Among Young women: Relationship to Induced Abortion, JNCI, 1994; 83:1584-1592 Decarli D, et al., Age At Any Birth and Breast Cancer Risk, International J of Cancer,1996, 67:187-189) Ewertz M, et al., Age at First Birth, Parity and Risk of Breast Cancer: A Meta-Analysis of 8 studies from the Nordic Countries, Int J Cancer, 1990, 46:597-603 Flamant R, et al., Familial Risk of Breast Cancer and Abortion, Can Detec & Prev, 1994, 18(1):51-55 Krieger N, Exposure, susceptibility, and breast cancer risk, Breast Cancer Res & Treatment, 1989, 13:205-213 Laing AE, et al.., Breast Cancer Risk Factors in African-American Women: The Howard University Tumor Registry Experience, JNMA, 1993, 85:931-939 Lyon JL, et al., Cancer incidence in Mormons and Non-Mormons in Utah During 1967-75, JNCI, 1980, 65:1055-1061 MacMahon B, et al., Age at First Birth and Breast Cancer Risk. Bulletin World Health Organization, 1970, 43:209-221 Olsson H, et al., Her-2/neu and INT2 Proto-oncogene Amplification in Malignant Breast Tumors in Relation to Reproductive Factors and Exposure to Exogenous Hormones, JNCI, 1991, 83:1483-1487 Petrakis N, et al., Influence of Pregnancy and Lactation on Serum and Breast Fluid Estrogen Levels: Implications for Breast Cancer Risk, Intl J Cancer, 1987; 40:587-591 Remennick LI, Reproductive Patterns and Cancer Incidence in Women: A Population-Based Correlation Study in the USSR, Int J Epi, 1989, 18:498- 510 Russo J, Russo IH, Susceptibility of the Mammary Gland to Carcinogenesis, Amer J Path, 1980, 100:497-512 Summy-Long J, et al., A Comparative Review and Meta-analysis of Abortion as an Independent Risk Factor for Breast Cancer, J Epidemiology and Community Health, 1996, 50:481-496 White Emily, Projected Changes in Breast Cancer Incidence due to the Trend toward Delayed Childbearing, Amer J Pub Health, 1987, 77:495-497 Yusa S, Trichopoulos D, et al., Age At Any Birth And Breast Cancer Risk, Int J Cancer, 1983, 31:701-704 ----------------------------------------------------------------------------- copyright Brent Rooney ( [email protected] )