C. Counter arguments against APB risk posed and answered Chapter B should have convinced an objective reader that the evidence for the APB (Abortion-Preterm-Birth) risk is very credible. In a malpractice suit in which the plaintiff claims that she was put at increased risk for preterm birth resulting in a handicapped child she had after prior elective induced abortions, the defense would like to demonstrate that the APB risk is not credible. Good 'LUCK' to such defense counsel!! How can defense counsel show that there is not one 'gold standard' APB study finding such a risk, when there are over forty such studies? How likely is it that defense counsel can demonstrate that top preterm birth experts such as Barbara Luke, Judith Lumley, and Emile Papiernik are not highly regarded experts in the field of prematurity risk? However, arguments to discredit the APB evidence will be presented. Here are some (not all!) of the arguments that could be presented, along with responses: 1. 'Recall Bias' - in any medical 'case-control' study it is possible , if interviews are used to collect data, that 'cases' (people with a particular disease) will be more accurate in recalling key information than are 'controls' (people without the particular disease). For example, if women with breast cancer are much more likely to admit to previous induced abortions than women without breast cancer, then one of 2 abortion-breast-cancer risks might be much less than researchers believe. (There is no strong evidence to support the contention that there is significant 'recall bias' for abortion-breast-cancer studies). Can doubters of the APB risk claim that 'recall bias' explains apparent risk and that there is no real risk? There is at least one (1) large population study that eliminated the possibility of 'recall bias' by using, not inter- views, but an abortion registry to ascertain induced abortion history.1 It is well known that in Greece there is no strong stigma against women with prior abortions.; ie. there is no good reason to believe that APB studies done in Greece are substantially affected by 'recall bias'. There are three (3) 'gold standard' Greek studies.9,15,18 How about the other 50+ 'gold standard' APB studies and 'recall bias'? The burden of proof is on the doubters to provide substantial evidence of 'recall bias'; a very heavy burden. Proving 'recall bias' for the APB risk is nearly an imposs- ible task. It is also possible for 'control' women in a case- control study to be more accurate in recalling reproductive events than are 'cases', in which situation the estimate of risk is too low, not too high! This possibility is virtually never mentioned by those supporting the health 'benefits' of induced abortion. 2. 'Socio-economic status' - if it is true that lower 'socio-economic status' women have more abortions than high SES women, then perhaps it is not the abortions that are responsible for PB risk, but low SES. This possibility was examined by preterm birth expert Judith Lumley (PhD) and discarded as very unlikely (20): Lumley reported the following relative risks of VPB from abortions: # prior induced % inc. in # prior spon. % inc. in relative abortions relative abortions risk of VPB VPB (<28 wks) (<28 weeks' gestation) risk 1 55% 1 66% 2 146% 2 194% 3 458% 3 489% Lumley wrote, "These last four relative risks [2.46, 2.94, 5.58, 5.89 ] are substantially greater than any of those associated with maternal age, marital status, parity or socio-economic status: that is the association is most unlikely to be explained by confounding factors of a sociodemographic kind."20 Let doubters argue with a highly regarded PB expert, Judith Lumley (Director: Centre for the Study of Womens' and Children's Health, Victoria, Australia) 3. APB has not been conclusively proven - this is probably true but is irrelevant, since for an elective procedure, warnings of risk must be given once there is credible evidence of risk. For example it has not been conclusively proven that hormone replacement therapy increases risk of breast cancer, but a doctor recommending this therapy must legally warn women (in particular, women with a family history of breast cancer) of the POSSIBLE breast cancer risk. In 1954 there was credible but not conclusive evidence that smoking cigarettes boosted lung cancer risk. No one would deny that warnings of POSSIBLE lung cancer risk should have been issued in 1954 by cigarette makers. Not warning until conclusive (or causal) evidence is produced is termed by some the 'Joe Camel' defense. 4. APB is not even an accepted PB risk - the APB risk is accepted by the author of the classic book in prematurity prevention, Prof. Barbara Luke.26 Two other giants in this field, Judith Lumley and Emile Papiernik have published results showing substantial APB risk. 10,19 No one denies that incompetent cervix boosts PB risk; incompe- tent cervix is a known risk of induced abortion surgery. Infection, particularly vaginal and intrauterine, is strongly suspected as a PB risk.26-31 5. Some APB review articles do not support the risk - a review article will take an overview of many previous studies. The claim of review articles not supporting APB is not true unless one takes the 'Joe Camel' position that conclusive proof must be found for there to be risk. Consider the 1999 study where the subjects were over 60,000 Danish women.1 The authors of this article in the respected medical journal Obstetrics and Gynecology wrote the following: "Three reviews ... concluded that dilation and evacuation increased the risk of preterm delivery."1 6. Some specific studies found no APB risk. The 'counter' to this type of argument is best demonstrated via example. Let's say defense council claims that the 1996 'Lang' study found no increased PB risk from precisely one previous induced abortion.3 The plaintiff, let's say, had precisely one previous induced abortion before she gave birth to a 'preemie' with a handicap. The 1996 'Lang' study found an increased risk of PB from one previous induced abortion of 10% but 'Lang' was not at least 95% confident of increased risk; in 'medical talk' this risk was reported as RR [Relative Risk] 1.1 (.8- 1.5); the first number in the parentheses, .8, is below 1.0 and tells one that the researchers were not at least 95% confident of higher risk. So, how can anyone say that there is no increase in risk according to 'Lang'? This is a common 'flippancy' in medical reports , since what researchers should honestly say is, "If there is indeed an increase in risk from factor X, then our study had too few sub- jects to be at least 95% confident of increased risk." Instead of an honest statement, what is often written is, "No increase in risk from factor X." However, the 'Lang' study did find a 90% increase in PB risk for women with two previous induced abortions (RR 1.9 (1. 1-3.0)); here the first number, 1.1, in parentheses is greater than 1.0, so for two induced abortions the 'gold standard' of at least 95% confidence was achieved. So what is the 'counter' to 'study xyx' found no APB risk? The counter is the following question: "What was the relative risk (RR) reported in this study?" The odds are high that either they do not know or if they can supply the RR number, it EXCEEDS 1.0 (i.e. increased risk). The comeback is, "So the researchers did report increased PB risk, but the study had too few subjects for them to be at least 95% confident of increased risk ." Since some of the 40+ 'gold standard' studies required 2 or 3 prior induced abortions for the researchers to be at least 95% con- fident of elevated risk, the 'ideal' plaintiff will have had at least two or three abortions before the 'preemie' with handicaps was born. Large population studies found significantly higher risk of PB with just one prior induced abortion.1,10,17 7. There are approximately 60 PB risk factors, so how can researchers be sure that the other 59 factors do not account for this risk?26 'Sure' is a 'code word' for a demand for conclusive proof of risk. It is clear that surgical induced abortions boost the risk of incom- petent cervix and infection, PB risk factors. Some consent forms admit to incompetent cervix (e.g. 'lacerated cervix') and many if not most forms admit to higher risk of infection. 'End of story'. 8. Studies finding APB did not properly adjust for all the other possi- ble risk factors - This means that perhaps there were differences between 'cases' (women with PB infants) and 'controls' (women with- out PB infants) other than abortion history that the researchers were unable to adjust for. There has never been a medical study that adjusted for all possible risk factors. Should one reject studies linking smoking to higher lung cancer risk, because differences in diet, exercise, location (urban vs. rural), marital status, ethnic background, reproductive history, etc. between 'cases' and 'controls' were not recorded and 'adjusted for'? No. If there were actually no PB or LBW (Low Birth Weight) risk from previous induced abortions, what are the odds that 40+ 'gold standard' studies would all find increased risk? What are the odds of fifty-nine flips of a two headed coin would result in all 'heads'? Ans: less than one in a trillion. Luke, Lumley, and Papiernik, three world class PB experts, reported elevated risk of PB from previous induced abortions. 9. Induced abortion techniques of the 1960's and 1970's may have caused PB risk, but vacuum aspiration does not - NICE TRY! Consider one recent (1999) study of over 60,000 Danish women.1 This study used an Induced Abortion Registry (started in 1973) and thus so- called 'recall bias' is not a possible explanation for a finding of APB risk. For vacuum aspiration the following risks were found(1): # previous vacuum relative increase 95% confidence aspiration in preterm birth interval abortions risk 1 82% (1.63,2.04)* 2 145% (1.90,3.17)* 3 100% (1.13,3.54)* * - all three finding achieved at least 95% confidence of increased PB risk So much for the theory that vacuum aspiration abortions carry no PB risk.1,10,17 10. Unless the relative APB risk is at least double (ie. RR 2.0), the risk can not be considered proven by a court. This is the 'cult of 2.0'. For an elective medical procedure, merely credible (not proven , conclusive, definitive, causal) proof of risk need be provided. For judges converted to the 'cult of 2.0', remind them of results that do surpass this 'magic' number. E.G. the 1998 German study results for VPB (Very Preterm Birth risk for gestations under 32 weeks')(17): # previous induced relative increase in abortions VPB risk 1 150% (RR 2.5)* 2 460% (RR 5.6)* 3 510% (RR 6.1)* (all three results exceeded a doubling of PB risk; * all three results achieved the 'gold standard' of at least 95% confidence) 11. No major medical organization recognizes APB risk - the Centers for Disease Control (Atlanta, Georgia) recognizes induced abortion as a risk factor for urinary/genital tract infection. Vaginal infection is a recognized risk for PB.26 Incompetent cervix is a recognized side-effect of induced abortion and incompetent cervix is a PB risk factor.26 Major U.S. medical organizations have been ineffective in stopping the continuing increases in U.S. PB rate, which is currently about 11 percent. Emile Papiernik (MD) was the head of a French program that reduced PB risk by 52% between 1972 and 1989 and a study he participated in found that abortions boost PB risk.19 For the fifty+ (50+) 'gold standard' studies reporting increased APB risk, consider some of the prestigious journals that these reports appeared in: New England Journal of Medicine (3 reports), British Medical Journal (2 reports), Obstetrics & Gynecology, American Journal of Public Health, American Journal of Epidemiology, American Journal of Obstetrics and Gynecology, Epidemiology, European Journal of Obstetrics & Gynecology and Reproductive Biology (3 reports) ...................................................................... SUMMARY: Some of the counter medical arguments against the APB risk have been presented, Clearly, the APB risk remains very credible. If the APB risk is not credible, then highly esteemed PB experts must demand that the New England Journal of Medicine expose THREE 'gold standard' studies published in it as invalid.4,5,6 Three world renowned PB experts, Luke, Lumley, and Papiernik must renounce their APB findings. Abortion clinics must remove warnings about incompetent cervix risk and infection risk from their consent forms. All of these actions must be taken for APB to lose substant- ial credibility, but none of them is likely to happen. APB is not merely a credible risk, it is a VERY credible risk for an ELECITVE (!!) medical procedure. copyright Brent Rooney ( [email protected] )